Thrombospondin-1 regulates the normal prostate in vivo through angiogenesis and TGF-β activation

@article{Fitchev2010Thrombospondin1RT,
  title={Thrombospondin-1 regulates the normal prostate in vivo through angiogenesis and TGF-β activation},
  author={Philip P Fitchev and Susan M Wcislak and Chung Ryul Lee and Anders Bergh and Charles B. Brendler and Veronica M Stellmach and Susan E Crawford and Constantine D. Mavroudis and Mona L. Cornwell and Jennifer A. Doll},
  journal={Laboratory Investigation},
  year={2010},
  volume={90},
  pages={1078-1090}
}
Castration experiments in rodents show that the stromal vasculature is critical to the androgen-mediated prostate growth regulation. However, the role of angiogenesis inhibitors, such as thrombospondin-1 (TSP-1), in this process is unclear. TSP-1 is a multifunctional glycoprotein that can function as a potent angiogenesis inhibitor and an in vivo activator of latent transforming growth factor-β (TGF-β) in some tissues. On the basis of these observations, we hypothesized that TSP-1 regulated… CONTINUE READING

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