Thrombospondin-1 promotes cellular adherence of gram-positive pathogens via recognition of peptidoglycan.

@article{Rennemeier2007Thrombospondin1PC,
  title={Thrombospondin-1 promotes cellular adherence of gram-positive pathogens via recognition of peptidoglycan.},
  author={Claudia Rennemeier and Sven Hammerschmidt and Silke Niemann and Seiichi Inamura and Ulrich Zaehringer and Beate E. Kehrel},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2007},
  volume={21 12},
  pages={3118-32}
}
Thrombospondin-1 (TSP1) is a matricellular glycoprotein that has key roles in interactions between human cells and components of the extracellular matrix. Here we report a novel role for the lectin TSP1 in pathogen-host interactions. Binding assays and flow cytometric analysis demonstrate that Streptococcus pneumoniae and other gram-positive pathogens including S. pyogenes, Staphylococcus aureus, and Listeria monocytogenes interact specifically with human TSP1. We also show for the first time… CONTINUE READING
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