Thrombospondin-1 limits ischemic tissue survival by inhibiting nitric oxide-mediated vascular smooth muscle relaxation.

@article{Isenberg2007Thrombospondin1LI,
  title={Thrombospondin-1 limits ischemic tissue survival by inhibiting nitric oxide-mediated vascular smooth muscle relaxation.},
  author={Jeff S. Isenberg and Fuminori Hyodo and Ken-ichiro Matsumoto and Martin J. Romeo and Mones Abu-Asab and Maria G Tsokos and Periannan Kuppusamy and David A Wink and Murali Cherukuri Krishna and David D. Roberts},
  journal={Blood},
  year={2007},
  volume={109 5},
  pages={
          1945-52
        }
}
The nitric oxide (NO)/cGMP pathway, by relaxing vascular smooth muscle cells, is a major physiologic regulator of tissue perfusion. We now identify thrombospondin-1 as a potent antagonist of NO for regulating F-actin assembly and myosin light chain phosphorylation in vascular smooth muscle cells. Thrombospondin-1 prevents NO-mediated relaxation of precontracted vascular smooth muscle cells in a collagen matrix. Functional magnetic resonance imaging demonstrated that an NO-mediated increase in… CONTINUE READING
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