Thrombospondin-1 is a novel negative regulator of liver regeneration after partial hepatectomy through transforming growth factor-beta1 activation in mice.

@article{Hayashi2012Thrombospondin1IA,
  title={Thrombospondin-1 is a novel negative regulator of liver regeneration after partial hepatectomy through transforming growth factor-beta1 activation in mice.},
  author={Hiromitsu Hayashi and Keiko Sakai and Hideo Baba and Takao Sakai},
  journal={Hepatology},
  year={2012},
  volume={55 5},
  pages={1562-73}
}
UNLABELLED The matricellular protein, thrombospondin-1 (TSP-1), is prominently expressed during tissue repair. TSP-1 binds to matrix components, proteases, cytokines, and growth factors and activates intracellular signals through its multiple domains. TSP-1 converts latent transforming growth factor-beta1 (TGF-β1) complexes into their biologically active form. TGF-β plays significant roles in cell-cycle regulation, modulation of differentiation, and induction of apoptosis. Although TGF-β1 is a… CONTINUE READING
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