Thrombospondin-1 in Early Flow-Related Remodeling of Mesenteric Arteries from Young Normotensive and Spontaneously Hypertensive Rats

@inproceedings{Lemkens2012Thrombospondin1IE,
  title={Thrombospondin-1 in Early Flow-Related Remodeling of Mesenteric
Arteries from Young Normotensive and Spontaneously Hypertensive Rats},
  author={Pieter Lemkens and Gem Boari and G. Fazzi and Gmj Janssen and Joanne E. Murphy-Ullrich and P. Schiffers and J. G. De Mey},
  booktitle={The open cardiovascular medicine journal},
  year={2012}
}
We tested the hypotheses that TSP-1 participates in the initiation of remodeling of small muscular arteries in response to altered blood flow and that the N-terminal domain of TSP-1 (hepI) can reverse the pathological inward remodeling of resistance arteries from SHR.We measured (1) changes in gene/protein expression in MA of 6 week old WKY and SHR exposed to either increased (+ 100 %) or reduced blood flow (- 90 %) for 24-40 hours and (2) structural changes in MA of 12 week old SHR exposed for… CONTINUE READING

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