Thrombospondin-1 binds to ApoER2 and VLDL receptor and functions in postnatal neuronal migration.

@article{Blake2008Thrombospondin1BT,
  title={Thrombospondin-1 binds to ApoER2 and VLDL receptor and functions in postnatal neuronal migration.},
  author={Sophia M Blake and Vera Strasser and Nuno Andrade and Sarah Duit and Reinhold Hofbauer and Wolfgang Johann Schneider and Johannes Nimpf},
  journal={The EMBO journal},
  year={2008},
  volume={27 22},
  pages={3069-80}
}
Apolipoprotein E receptor 2 (ApoER2), very low-density lipoprotein receptor (VLDLR), and Dab1 are the main components of the Reelin signalling cascade. Reelin is the sole ligand defined so far in signalling through this pathway. Postnatal migration of neuronal precursors from the subventricular zone (SVZ) to the olfactory bulb (OB), however, depends on ApoER2 and Dab1, but functions independently of Reelin. Here, we show that thrombospondin-1 (THBS-1) is a novel physiological ligand for ApoER2… CONTINUE READING