Thrombospondin-1/CD47 blockade following ischemia-reperfusion injury is tissue protective.


BACKGROUND Nitric oxide has prosurvival effects that can limit ischemia-reperfusion injuries. However, the matrix glycoprotein thrombospondin-1 is induced following ischemia-reperfusion injury and limits nitric oxide signaling by engaging its cell surface receptor CD47. In this article, the authors examine whether postinjury blocking of this inhibitory… (More)
DOI: 10.1097/PRS.0b013e3181bceec3


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