Thrombospondin-1, vascular endothelial growth factor and fibroblast growth factor-2 are key functional regulators of angiogenesis in the prostate.

@article{Doll2001Thrombospondin1VE,
  title={Thrombospondin-1, vascular endothelial growth factor and fibroblast growth factor-2 are key functional regulators of angiogenesis in the prostate.},
  author={Jennifer A. Doll and Frank K Reiher and Susan E Crawford and Michael R. Pins and Steven C Campbell and No{\"e}l P. Bouck},
  journal={The Prostate},
  year={2001},
  volume={49 4},
  pages={293-305}
}
BACKGROUND Prostate cells secrete many molecules capable of regulating angiogenesis; however, which of these actually function as essential regulators of neovascularization is not yet clear. METHODS Functional angiogenic mediators secreted by normal and diseased prostate cells were identified using an in vitro angiogenesis assay. These factors were quantified by immunoblot or ELISA and localized in tissue by immunohistochemistry. RESULTS Normal prostate epithelial cell secretions were anti… CONTINUE READING
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