Thrombospondin-1, an inhibitor of angiogenesis, is regulated by progesterone in the human endometrium.

@article{IruelaArispe1996Thrombospondin1AI,
  title={Thrombospondin-1, an inhibitor of angiogenesis, is regulated by progesterone in the human endometrium.},
  author={M. Luisa Iruela-Arispe and Peggy L. Porter and Paul Bornstein and E. Helene Sage},
  journal={The Journal of clinical investigation},
  year={1996},
  volume={97 2},
  pages={
          403-12
        }
}
Thrombospondin-1 (TSP1), a multifunctional extracellular matrix glycoprotein, has been shown to suppress the angiogenic response in vivo and in vitro. We hypothesized that TSP1 might play a role in the inhibition of capillary morphogenesis during the endometrial cycle and examined its expression in 46 human endometrial specimens. Our results show that the expression of TSP1 in the endometrium is (a) cycle-dependent, (b) associated with periods of low capillary growth, and (c) regulated by… CONTINUE READING

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