Thrombosis and sickle cell disease.

  title={Thrombosis and sickle cell disease.},
  author={Lucia De Franceschi and Maria Domenica Cappellini and Oliviero Olivieri},
  journal={Seminars in thrombosis and hemostasis},
  volume={37 3},
Sickle cell disease (SCD) is characterized by the presence of sickle hemoglobin, which has the unique property of polymerizing when deoxygenated. The pathophysiology of acute and chronic clinical manifestations of SCD have shown the central role of dense, dehydrated red cells in acute and chronic clinical manifestations of this pathology. Recent studies have indicated that SCD is characterized by a hypercoagulable state that contributes to the vaso-occlusive events in microcirculation, leading… CONTINUE READING