Thrombosis and haemorrhage in polycythaemia vera and essential thrombocythaemia.

  title={Thrombosis and haemorrhage in polycythaemia vera and essential thrombocythaemia.},
  author={Michelle A Elliott and Ayalew Tefferi},
  journal={British journal of haematology},
  volume={128 3},
Despite decades of clinical and laboratory research, relatively little has been accomplished concerning the pathogenesis as well as the identification of risk factors for thrombosis and bleeding in myeloproliferative disorders. In polycythaemia vera, the pro-thrombotic effect of an elevated haematocrit is well established. In contrast, thrombocytosis per se has not been similarly incriminated in essential thrombocythaemia. In both conditions, advanced age and the presence of a prior event… CONTINUE READING