Thrombosis and ELISA optical density values in hospitalized patients with heparin-induced thrombocytopenia.

@article{Zwicker2004ThrombosisAE,
  title={Thrombosis and ELISA optical density values in hospitalized patients with heparin-induced thrombocytopenia.},
  author={Jeffrey I Zwicker and Lynn Uhl and W-Y Huang and Beth H Shaz and Kenneth A. Bauer},
  journal={Journal of thrombosis and haemostasis : JTH},
  year={2004},
  volume={2 12},
  pages={2133-7}
}
The natural history of heparin-induced thrombocytopenia (HIT) in the absence of thrombosis was previously established using functional assays for confirmation of diagnosis (e.g. 14C serotonin release assay). An enzyme-linked immunosorbent assay (ELISA) that detects the presence of antibodies directed against the heparin-platelet factor-4 (PF4) complex has largely replaced functional assays in many medical centers. Although the ELISA is highly sensitive for detecting HIT antibodies, its… CONTINUE READING
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