Thrombopoietin promotes hematopoietic recovery and survival after high-dose whole body irradiation.

@article{Mouthon1999ThrombopoietinPH,
  title={Thrombopoietin promotes hematopoietic recovery and survival after high-dose whole body irradiation.},
  author={M A Mouthon and Anne Van der Meeren and M H Gaugler and Trudi P. Visser and Claire Squiban and Patrick Gourmelon and Gerard Wagemaker},
  journal={International journal of radiation oncology, biology, physics},
  year={1999},
  volume={43 4},
  pages={867-75}
}
PURPOSE The therapeutic potential of thrombopoietin (TPO), the major regulator of platelet production, was evaluated for hematopoietic recovery and survival in mice following lethal and supralethal total body irradiation (TBI). METHODS AND MATERIALS Hematopoietic recovery was studied in C57BL6/J mice after 8 Gy TBI (gamma-rays). Survival experiments were performed with C57BL6/J and BCBA F1 mice. Two protocols of TPO administration were evaluated: treatment for 7 consecutive days (7 x 0.3… CONTINUE READING
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