Thrombopoietin induces production of nucleated thrombocytes from liver cells in Xenopus laevis

@inproceedings{Tanizaki2015ThrombopoietinIP,
  title={Thrombopoietin induces production of nucleated thrombocytes from liver cells in Xenopus laevis},
  author={Yuta Tanizaki and Megumi Ichisugi and Miyako Obuchi-Shimoji and Takako Ishida-Iwata and Ayaka Tahara-Mogi and Mizue Meguro-Ishikawa and Takashi Kato},
  booktitle={Scientific reports},
  year={2015}
}
The development of mammalian megakaryocytes (MKs) and platelets, which are thought to be absent in non-mammals, is primarily regulated by the thrombopoietin (TPO)/Mpl system. Although non-mammals possess nucleated thrombocytes instead of platelets, the features of nucleated thrombocyte progenitors remain to be clarified. Here, we provide the general features of TPO using Xenopus laevis TPO (xlTPO). Hepatic and splenic cells were cultured in liquid suspension with recombinant xlTPO. These cells… CONTINUE READING
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