Thrombopoietin induces megakaryocyte differentiation in hematopoietic progenitor FDC-P2 cells.

@article{Nagata1995ThrombopoietinIM,
  title={Thrombopoietin induces megakaryocyte differentiation in hematopoietic progenitor FDC-P2 cells.},
  author={Yuka Nagata and H Nagahisa and Yoshitomi Aida and Kei-ichi Okutomi and Toshiro Nagasawa and Kazuo Todokoro},
  journal={The Journal of biological chemistry},
  year={1995},
  volume={270 34},
  pages={19673-5}
}
Thrombopoietin (Tpo) is a cytokine that specifically regulates megakaryocyte maturation and platelet production. Little is known about the molecular and cellular mechanism of the Tpo-induced megakaryocyte maturation process including polyploidization and platelet release. To study Tpo-induced megakaryocyte differentiation, a mouse cell line FD-TPO, which responds and grows with Tpo, was established from a interleukin-3-dependent hematopoietic progenitor cell line FDC-P2. The FD-TPO cells… CONTINUE READING

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