Thrombopoietin induces an SH2-containing protein, CIS1, which binds to Mpl: involvement of the ubiquitin proteosome pathway.

@article{Okabe1999ThrombopoietinIA,
  title={Thrombopoietin induces an SH2-containing protein, CIS1, which binds to Mpl: involvement of the ubiquitin proteosome pathway.},
  author={Shigeo Okabe and Testuzo Tauchi and Haruhiko Morita and Haruhiko Ohashi and Akihiko Yoshimura and Kazuma Ohyashiki},
  journal={Experimental hematology},
  year={1999},
  volume={27 10},
  pages={1542-7}
}
The interaction of thrombopoietin (TPO) with its receptor, Mpl, triggers growth and differentiation of megakaryocytes and their progenitors. The Mpl cytoplasmic domain controls this process through src homology 2 (SH2)-containing target molecules and their receptor docking sites. A novel cytokine inducible SH2-containing protein, CIS1, has been isolated. CIS1 is induced by interleukin-2 (IL-2), IL-3, GM-CSF, and erythropoietin (EPO), but not by IL-6, granulocyte colony-stimulating factor (G-CSF… CONTINUE READING
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