• DOI:10.1111/bjh.12772
Corpus ID: 39360961

Thrombopoietin from beginning to end

@article{Hitchcock2014ThrombopoietinFB,
  title={Thrombopoietin from beginning to end},
  author={I. Hitchcock and K. Kaushansky},
  journal={British Journal of Haematology},
  year={2014},
  volume={165}
}

I. Hitchcock, K. Kaushansky

Published 2014

Biology, Medicine

British Journal of Haematology

In the two decades since its cloning, thrombopoietin (TPO) has emerged not only as a critical haematopoietic cytokine, but also serves as a great example of bench‐to‐bedside research. Thrombopoietin, produced by the liver, is the primary regulator of megakaryocyte progenitor expansion and differentiation. Additionally, as TPO is vital for the maintenance of haematopoietic stem cells, it can truly be described as a pan‐haematopoietic cytokine. Since recombinant TPO became available, the… CONTINUE READING

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