Thrombopoietin from beginning to end

  title={Thrombopoietin from beginning to end},
  author={I. Hitchcock and K. Kaushansky},
  journal={British Journal of Haematology},
  • I. Hitchcock, K. Kaushansky
  • Published 2014
  • Biology, Medicine
  • British Journal of Haematology
  • In the two decades since its cloning, thrombopoietin (TPO) has emerged not only as a critical haematopoietic cytokine, but also serves as a great example of bench‐to‐bedside research. Thrombopoietin, produced by the liver, is the primary regulator of megakaryocyte progenitor expansion and differentiation. Additionally, as TPO is vital for the maintenance of haematopoietic stem cells, it can truly be described as a pan‐haematopoietic cytokine. Since recombinant TPO became available, the… CONTINUE READING
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