Thrombopoietin enhances the alpha IIb beta 3-dependent adhesion of megakaryocytic cells to fibrinogen or fibronectin through PI 3 kinase.

@article{Zauli1997ThrombopoietinET,
  title={Thrombopoietin enhances the alpha IIb beta 3-dependent adhesion of megakaryocytic cells to fibrinogen or fibronectin through PI 3 kinase.},
  author={Giorgio Zauli and Alessandra Bassini and Marco Vitale and Davide Gibellini and Claudio Celeghini and Elisabetta Caramelli and Sabina Pierpaoli and Lia Guidotti and Silvano Capitani},
  journal={Blood},
  year={1997},
  volume={89 3},
  pages={883-95}
}
The effect of thrombopoietin (TPO) on the functional activity of surface alpha IIb beta 3 (GPIIbIIIa) was investigated in both primary human megakaryocytic cells, derived from peripheral blood CD34+ cells, and HEL hematopoietic cell line. TPO (100 ng/mL) induced a sixfold to ninefold enhancement of adhesion of both primary megakaryocytic and HEL cells to… CONTINUE READING