Thrombopoietin and interleukin 11 have different modulatory effects on cell cycle and programmed cell death in primary acute myeloid leukemia cells.

@article{Tafuri1999ThrombopoietinAI,
  title={Thrombopoietin and interleukin 11 have different modulatory effects on cell cycle and programmed cell death in primary acute myeloid leukemia cells.},
  author={Agostino Tafuri and Roberto Massimo Lemoli and Maria Teresa Petrucci and Maria Rosaria Ricciardi and M. Fogli and Laura Bonsi and Cristina Ariola and Pierluigi Strippoli and Chiara Gregorj and Maria Concetta Petti and Sante Tura and Franco Mandelli and Gian Paolo Bagnara},
  journal={Experimental hematology},
  year={1999},
  volume={27 8},
  pages={1255-63}
}
The c-mpl ligand, thrombopoietin (TPO), is a physiologic regulator of platelet and megakaryocytic production, acting synergistically on thrombopoiesis with the growth factors interleukin 11 (IL-11), stem cell factor, interleukin 3 (IL-3), interleukin 6 (IL-6), and granulocyte-macrophage colony-stimulating factor. Because some of these growth factors, especially TPO and IL-11, are now being evaluated clinically to reduce chemotherapy-associated thrombocytopenia in cancer patients, we evaluated… CONTINUE READING