Thrombopoietin accelerates platelet, red blood cell, and neutrophil recovery in myelosuppressed mice.

@article{Grossmann1996ThrombopoietinAP,
  title={Thrombopoietin accelerates platelet, red blood cell, and neutrophil recovery in myelosuppressed mice.},
  author={Angelika Grossmann and Jason Lenox and Huiming Ren and J M Humes and John W. Forstrom and Kenneth Kaushansky and K H Sprugel},
  journal={Experimental hematology},
  year={1996},
  volume={24 10},
  pages={1238-46}
}
The recent cloning of thrombopoietin (TPO) has allowed us to study its in vivo effects in normal and myelosuppressed mice. Normal Balb/c mice were treated with recombinant human TPO (hTPO) at doses ranging from 1 to 20 kU for 7 days, and complete blood counts (CBCs) and the number of megakaryocytes in the bone marrow were determined. Platelet counts were increased starting on day 5 after mice were treated with hTPO. Platelet counts reached a peak between days 8 and 11 and returned to baseline… CONTINUE READING