Thrombopoietin: a tool for understanding thrombopoiesis.

  title={Thrombopoietin: a tool for understanding thrombopoiesis.},
  author={Kenneth Kaushansky},
  journal={Journal of thrombosis and haemostasis : JTH},
  volume={1 7},
Although first proposed to be the primary regulator of platelet production 45 years ago, the gene for thrombopoietin was cloned only within the last decade. Since then, our understanding of megakaryocyte and platelet production has increased substantially, and it is now appreciated that in addition to its critical role in regulating thrombopoiesis, the hormone affects multiple aspects of hematopoiesis, including playing a non-redundant role in stem cell survival, self-renewal and expansion. In… CONTINUE READING