Thrombopoietic potential and serial repopulating ability of murine hematopoietic stem cells constitutively expressing interleukin 11.

@article{Hawley1996ThrombopoieticPA,
  title={Thrombopoietic potential and serial repopulating ability of murine hematopoietic stem cells constitutively expressing interleukin 11.},
  author={Robert G. Hawley and Teresa S. Hawley Robert G. Hawley and Andrew Z. C. Fong and Carmen Quinto and Mary Collins and John P. Leonard and Samuel J. Goldman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1996},
  volume={93 19},
  pages={10297-302}
}
Based on transplantation studies with bone marrow cultured under various conditions, a role of interleukin 11 (IL-11) in the self-renewal and/or the differentiation commitment of hematopoietic stem cells has been indicated. To better evaluate the in vivo effects of IL-11 on stem/progenitor cell biology, lethally irradiated mice were serially transplanted with bone marrow cells transduced with a defective retrovirus, termed MSCV-mIL-11, carrying the murine IL-11 (mIL-11) cDNA and the bacterial… CONTINUE READING

5 Figures & Tables

Connections & Topics

Mentioned Connections BETA
Collectively , these data show that persistent stimulation of platelet production by IL-11 is not detrimental to stem cell repopulating ability ; rather , they suggest that IL-11 expression in vivo may have resulted in enhanced maintenance of the most primitive hematopoietic stem cell compartment .
Collectively , these data show that persistent stimulation of platelet production by IL-11 is not detrimental to stem cell repopulating ability ; rather , they suggest that IL-11 expression in vivo may have resulted in enhanced maintenance of the most primitive hematopoietic stem cell compartment .
All Topics