Abstract

Thrombopoietin (TPO) is the key cytokine involved in thrombopoiesis, and is the endogenous ligand for the thrombopoietin receptor that is expressed on the surface of platelets, megakaryocytes, and megakaryocytic precursors. First-generation thrombopoietic agents were recombinant forms of human TPO, and their development was discontinued after prolonged… (More)
DOI: 10.1016/j.blre.2010.04.002

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@article{Stasi2010ThrombopoieticA, title={Thrombopoietic agents.}, author={Roberto Stasi and Jenny Bosworth and Elizabeth Rhodes and Muriel S. Shannon and Fenella Willis and Edward C. Gordon-Smith}, journal={Blood reviews}, year={2010}, volume={24 4-5}, pages={179-90} }