Thromboplastic factors in platelets and red blood cells: observations on their chemical nature and function in vitro coagulation.

@article{Troup1960ThromboplasticFI,
  title={Thromboplastic factors in platelets and red blood cells: observations on their chemical nature and function in vitro coagulation.},
  author={S B Troup and Charles F. Reed and Guido V. Marinetti and S N Swisher},
  journal={The Journal of clinical investigation},
  year={1960},
  volume={39},
  pages={342-51}
}
Although the existence of blood platelets had been known for many years it was not until 1882 that Bizzozero (1) called attention to the role of platelets in blood coagulation. Morawitz (2), twenty years later, was among the first to consider the specific chemical contribution of the platelet to the clotting process. Howell (3), in 1912, demonstrated the presence of an unsaturated phosphatide ("kephalin") in thromboplastic substances of tissue origin. Mills (4), in 1927, showed cephalin to be… CONTINUE READING