Thrombomodulin as an intravascular safeguard against inflammatory and thrombotic diseases

@article{Ito2016ThrombomodulinAA,
  title={Thrombomodulin as an intravascular safeguard against inflammatory and thrombotic diseases},
  author={Takashi Ito and Yasuyuki Kakihana and Ikuro Maruyama},
  journal={Expert Opinion on Therapeutic Targets},
  year={2016},
  volume={20},
  pages={151 - 158}
}
Introduction: Thrombomodulin is a transmembrane protein expressed on the surface of endothelial cells. It plays an important role in regulating inflammation as well as coagulation within blood vessels. Recently, a recombinant form of an extracellular fragment of thrombomodulin (rTM) has been developed and is expected to be useful for patients suffering from inflammatory and thrombotic diseases. Areas covered: We initially focus on the physiological and biochemical features of thrombomodulin… Expand
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