Thrombomodulin activity on mesothelial cells: perspectives for mesothelial cells as an alternative for endothelial cells for cell seeding on vascular grafts

@article{Verhagen1996ThrombomodulinAO,
  title={Thrombomodulin activity on mesothelial cells: perspectives for mesothelial cells as an alternative for endothelial cells for cell seeding on vascular grafts},
  author={Hendricus Martinus Christianus Verhagen and G J Heijnen-Snyder and Apollo Pronk and Thea M. Vroom and Th. J. M. V. van Vroonhoven and Bert C. Eikelboom and Jan J. Sixma and PhG de Groot},
  journal={British Journal of Haematology},
  year={1996},
  volume={95}
}
Lining the luminal surface of prosthetic small diameter bypasses with endothelial cells (EC) will lower its thrombogenicity. Unfortunately, human EC are scarce. Mesothelial cells (MC) may be a valuable alternative for EC, since they are abundantly available and have antithrombotic and fibrinolytic properties. An important anticoagulant function of EC is due to thrombomodulin (TM) on the surface. The presence of TM on omentally derived human MC is not known but would increase the chance of… 

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Tissue factor expression on mesothelial cells is induced during in vitro culture--manipulation of culture conditions creates perspectives for mesothelial cells as a source for cell seeding procedures on vascular grafts.

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