Thrombomodulin Attenuates Inflammatory Damage Due to Liver Ischemia and Reperfusion Injury in Mice in Toll‐Like Receptor 4–Dependent Manner

@article{Kadono2017ThrombomodulinAI,
  title={Thrombomodulin Attenuates Inflammatory Damage Due to Liver Ischemia and Reperfusion Injury in Mice in Toll‐Like Receptor 4–Dependent Manner},
  author={K. Kadono and Y. Uchida and H. Hirao and T. Miyauchi and T. Watanabe and T. Iida and S. Ueda and A. Kanazawa and A. Mori and H. Okajima and H. Terajima and S. Uemoto},
  journal={American Journal of Transplantation},
  year={2017},
  volume={17},
  pages={69 - 80}
}
Liver ischemia reperfusion injury (IRI) is an important problem in liver transplantation. Thrombomodulin (TM), an effective drug for disseminated intravascular coagulation, is also known to exhibit an anti‐inflammatory effect through binding to the high‐mobility group box 1 protein (HMGB‐1) known as a proinflammatory mediator. We examined the effect of recombinant human TM (rTM) on a partial warm hepatic IRI model in wild‐type (WT) and toll‐like receptor 4 (TLR‐4) KO mice focusing on the HMGB‐1… Expand
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