Thrombolytic therapy in peripheral arterial occlusive disease: mechanisms of action and drugs available.

@article{Comerota1993ThrombolyticTI,
  title={Thrombolytic therapy in peripheral arterial occlusive disease: mechanisms of action and drugs available.},
  author={Anthony James Comerota and Gary S. Cohen},
  journal={Canadian journal of surgery. Journal canadien de chirurgie},
  year={1993},
  volume={36 4},
  pages={342-8}
}
Catheter-directed thrombolytic therapy has become an important part of the treatment of patients with acute arterial and graft occlusion. The underlying pharmacologic principle is the activation of plasminogen, bound to fibrin within the thrombus. Guide-wire passage reliably predicts success of catheter-directed thrombolysis. The underlying disease process… CONTINUE READING