Thrombolytic therapy for stroke in patients with preexisting cognitive impairment.

  title={Thrombolytic therapy for stroke in patients with preexisting cognitive impairment.},
  author={Kei Murao and Didier Leys and Agn{\`e}s Jacquin and Takanari Kitazono and R{\'e}gis Bordet and Yannick B{\'e}jot and Kazumi Kimura and Olivier Godefroy and Yoshinobu Wakisaka and Sol{\`e}ne Moulin and Tetsuro Ago and Igor Sibon and Stephanie Bombois and J R Perez Mas and Hilde H{\'e}non and Florence Pasquier and Maurice Giroud and Charlotte Cordonnier and Yasushi Okada},
  volume={82 23},
OBJECTIVE We aimed to evaluate the influence of prestroke cognitive impairment (PSCI) on outcomes in stroke patients treated with IV recombinant tissue plasminogen activator (rtPA). METHODS OPHELIE-COG was a prospective observational multicenter study conducted in French and Japanese patients treated with IV rtPA for cerebral ischemia. The preexisting cognitive status was evaluated by the short version of the Informant Questionnaire on Cognitive Decline in the Elderly. PSCI was defined as a… CONTINUE READING

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