Thrombolytic removal of intraventricular haemorrhage in treatment of severe stroke: results of the randomised, multicentre, multiregion, placebo-controlled CLEAR III trial.

@article{Hanley2017ThrombolyticRO,
  title={Thrombolytic removal of intraventricular haemorrhage in treatment of severe stroke: results of the randomised, multicentre, multiregion, placebo-controlled CLEAR III trial.},
  author={Daniel F. Hanley and Karen Lane and Nichol A McBee and Wendy C. Ziai and Stanley Tuhrim and Kennedy R. Lees and Jesse Dawson and D Gandhi and Natalie L. Ullman and W. Andrew Mould and Steven W. Mayo and A. David Mendelow and Barbara Gregson and K. Scott Butcher and Paul M. Vespa and David D. Wright and Carlos S. Kase and Juan Ricardo Carhuapoma and Penelope M Keyl and Marie Diener-West and John Muschelli and Joshua Francis Betz and C B Thompson and Elizabeth A. Sugar and Gayane Yenokyan and Scott Janis and Sayona John and S Harnof and George A. Lopez and Enslin Francois Aldrich and M R Harrigan and Safdar Ansari and Jack I. Jallo and J Caron and D. C. LeDoux and Opeolu Adeoye and Mario Zuccarello and Harold P. Adams and Michael Aaron Rosenblum and Richard E. Thompson and I A Awad},
  journal={Lancet},
  year={2017},
  volume={389 10069},
  pages={
          603-611
        }
}
BACKGROUND Intraventricular haemorrhage is a subtype of intracerebral haemorrhage, with 50% mortality and serious disability for survivors. We aimed to test whether attempting to remove intraventricular haemorrhage with alteplase versus saline irrigation improved functional outcome. METHODS In this randomised, double-blinded, placebo-controlled, multiregional trial (CLEAR III), participants with a routinely placed extraventricular drain, in the intensive care unit with stable, non-traumatic… CONTINUE READING
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