Thrombolytic properties of a novel modified human tissue-type plasminogen activator (E6010): a bolus injection of E6010 has equivalent potency of lysing young and aged canine coronary thrombi.

@article{Suzuki1991ThrombolyticPO,
  title={Thrombolytic properties of a novel modified human tissue-type plasminogen activator (E6010): a bolus injection of E6010 has equivalent potency of lysing young and aged canine coronary thrombi.},
  author={S. Y. Suzuki and Muneyasu Saito and Noriyuki Suzuki and Hideo Kato and Noriyuki Nagaoka and Shimako Yoshitake and Hitoshi Mizuo and Teruaki Yuzuriha and Yoshiki Yui and Chuichi Kawai},
  journal={Journal of cardiovascular pharmacology},
  year={1991},
  volume={17 5},
  pages={738-46}
}
The thrombolytic properties of a novel modified human tissue plasminogen activator (E6010), in which cystein 84 in the epidermal growth factor domain is replaced by serine and that has a prolonged biological half-life, were examined. The thrombolytic efficacies of E6010 and recombinant human tissue plasminogen activator (rt-PA) on the duration of coronary artery thrombus were evaluated in a canine model (123 anesthetized dogs) with copper coil-induced left anterior descending coronary artery… CONTINUE READING

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