Thrombolytic efficacy and enzymatic activity of rt-PA-loaded echogenic liposomes

@inproceedings{Bader2015ThrombolyticEA,
  title={Thrombolytic efficacy and enzymatic activity of rt-PA-loaded echogenic liposomes},
  author={Kenneth B. Bader and Guillaume Bouchoux and Tao Peng and Melvin E Klegerman and David D. McPherson and Christy K. Holland},
  booktitle={Journal of Thrombosis and Thrombolysis},
  year={2015}
}
Echogenic liposomes (ELIP), that can encapsulate both recombinant tissue-type plasminogen activator (rt-PA) and microbubbles, are under development to improve the treatment of thrombo-occlusive disease. However, the enzymatic activity, thrombolytic efficacy, and stable cavitation activity generated by this agent has yet to be evaluated and compared to another established ultrasound-enhanced thrombolytic scheme. A spectrophotometric method was used to compare the enzymatic activity of the rt-PA… CONTINUE READING
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