Thrombolytic agents--an overview.

  title={Thrombolytic agents--an overview.},
  author={Dietrich C. Gulba and Christoph Bode and Marschall S. Runge and Kurt Huber},
  journal={Annals of hematology},
  volume={73 Suppl 1},
Thrombolysis today has become a routine option not only in the treatment of acute myocardial infarction but also in many other manifestations of thromboembolic disease. Until one decade ago, only two plasminogen activators, streptokinase and urokinase, were available for clinical use. They were characterized by limited thrombolytic potencies and major side effects including systemic fibrinogen breakdown, bleeds and stroke. This has prompted the search for new plasminogen activators with better… CONTINUE READING
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