Thrombolysis in acute ischaemic stroke: time for a rethink?

@article{Alper2015ThrombolysisIA,
  title={Thrombolysis in acute ischaemic stroke: time for a rethink?},
  author={Brian S. Alper and Meghan Malone-Moses and James S. McLellan and Kameshwar Prasad and Eric W. Manheimer},
  journal={BMJ : British Medical Journal},
  year={2015},
  volume={350}
}
As the UK regulator reviews alteplase in ischaemic stroke, Brian Alper and colleagues interpret the evidence to suggest increased mortality with uncertain benefit for its use beyond three hours 
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