Thrombogenesis in sickle cell disease.

  title={Thrombogenesis in sickle cell disease.},
  author={Ahron Tomer and Laurence A. Harker and Suha Kasey and James R. Eckman},
  journal={The Journal of laboratory and clinical medicine},
  volume={137 6},
Thirty-three subjects with sickle cell disease (SCD), 11 during episodes of pain and 22 during periods without pain, were evaluated for in vivo thrombogenic activities as compared with 10 normal black control subjects. Measurements were performed for (1) platelet surface activation, assessing flow cytometric expression of activated integrin alpha(IIb)beta(3) receptor (GPIIb/IIIa, CD41a) and P-selectin (CD62p); (2) platelet and erythrocyte surface procoagulant activities, measuring flow… CONTINUE READING


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