Thrombocytopenia in the First 24 Hours After Birth and Incidence of Patent Ductus Arteriosus

@article{Sallmon2012ThrombocytopeniaIT,
  title={Thrombocytopenia in the First 24 Hours After Birth and Incidence of Patent Ductus Arteriosus},
  author={Hannes Sallmon and Sven C. Weber and Britta H{\"u}ning and Anja Stein and Peter A. Horn and Boris Metze and Christof Dame and Christoph B{\"u}hrer and Ursula Felderhoff-M{\"u}ser and Georg Hansmann and Petra S Koehne},
  journal={Pediatrics},
  year={2012},
  volume={130},
  pages={e623 - e630}
}
BACKGROUND Experimental studies suggest that platelet-triggered ductal sealing is critically involved in definite ductus arteriosus closure. [] Key Method This was a retrospective study of 1350 very low birth weight (VLBW; <1500 g) infants, including 592 extremely low birth weight (ELBW; <1000 g) infants. METHODS All infants who had a platelet count in the first 24 hours after birth and an echocardiogram performed on day of life 4 to 5 were included.
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43 Citations
Highly Influential Citations
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Background Citations
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Methods Citations
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Results Citations
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43 Citations

Citation Type

Citation Type

Platelet Counts in the First Seven Days of Life and Patent Ductus Arteriosus in Preterm Very Low-Birth-Weight Infants
TLDR
The data provide further evidence for the lack of association between platelet counts within the first days of life and either spontaneous or pharmacological closure of the ductus arteriosus in VLBW infants.
Is the First Postnatal Platelet Mass as an Indicator of Patent Ductus Arteriosus?
TLDR
The data suggest that platelet count, MPV, and platelet mass do not contribute to closure of PDA in premature newborns.
The Thromboelastographic Profile at Birth in Very Preterm Newborns with Patent Ductus Arteriosus
TLDR
TEG at birth does not predict spontaneous PDA closure in preterm newborns and fibrinolysis is enhanced in nonresponders to PDA treatment; this observation warrants further investigation.
Mature and immature platelets during the first week after birth and incidence of patent ductus arteriosus
TLDR
During the first week of postnatal life, lower counts of mature platelets and higher immature platelet fraction values are associated with haemodynamically significant patent ductus arteriosus.
Association between Platelet Counts before and during Pharmacological Therapy for Patent Ductus Arteriosus and Treatment Failure in Preterm Infants
TLDR
Evidence is provided for an association between low platelet counts during pharmacological therapy for symptomatic PDA and treatment failure, while platelet Counts before initiation of therapy did not affect treatment outcome.
Platelets and platelet-derived growth factor in closure of the ductus arteriosus.
TLDR
It is suggested that platelet-derived growth factor may play a role in ductal closure independent from platelet count and might be used as an adjunct surrogate for prediction of future need for treatment for hemodynamically significant patent ductus arteriosus in preterm infants.
Is there a relationship between platelet parameters and patency of ductus arteriosus in preterm infants?
TLDR
This single-center, retrospective study included 824 premature infants between 24 and 34 gestational weeks and could not demonstrate an association between any platelet parameter and either persistence or closure after medical treatment, unlike most reports in the literature.
Current Controversy on Platelets and Patent Ductus Arteriosus Closure in Preterm Infants
TLDR
The available evidence suggests that thrombocytopenia and platelet dysfunction contribute to failure of spontaneous and pharmacological PDA closure in preterm infants, but these platelet effects on PDA seem to be of only moderate clinical significance.
Does platelet mass influence the effectiveness of ibuprofen treatment for patent ductus arteriosus in preterm infants?
  • S. Akar, N. Karadag, +9 authors F. Ovalı
  • Medicine
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
  • 2016
TLDR
The data suggest that platelet count, MPV and platelet mass did not affect the closure of hsPDA with ibuprofen.
Platelet Counts and Patent Ductus Arteriosus in Preterm Infants: A Systematic Review and Meta-Analysis
TLDR
A meta-analysis of all the studies addressing the relationship between platelet counts in the first day(s) of life and patent ductus arteriosus (PDA) in preterm infants reveals a marginal but significant association.
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References

SHOWING 1-10 OF 39 REFERENCES
Prevalence of Spontaneous Closure of the Ductus Arteriosus in Neonates at a Birth Weight of 1000 Grams or Less
TLDR
Spontaneous permanent DA closure occurs in >34% of ELBW neonates and is predicted by variables related to maturation, for example, EGA and an absence of HMD, whereas indomethacin failure could not be predicated.
Relationship between circulating platelet counts and ductus arteriosus patency after indomethacin treatment.
Ductal closure in neonates: a developmental perspective on platelet-endothelial interactions.
TLDR
The understanding of the mechanisms underlying ductus arteriosus closure is of pivotal clinical importance especially for preterm infants.
A comparison of ibuprofen and indomethacin for closure of patent ductus arteriosus.
Ibuprofen for the treatment of patent ductus arteriosus in preterm and/or low birth weight infants.
TLDR
There were no statistically significant differences in mortality, surgical duct ligation, duration of ventilator support, IVH, PVL, NEC, decreased urine output, retinopathy of prematurity, and weighted mean difference (WMD), all with 95% confidence intervals (CI).
Timing of patent ductus arteriosus treatment and respiratory outcome in premature infants: a double-blind randomized controlled trial.
Patent ductus arteriosus: are current neonatal treatment options better or worse than no treatment at all?
TLDR
New information suggests that early pharmacologic treatment has several important short-term benefits for the preterm newborn, and ductus ligation, while eliminating the detrimental effects of a PDA on lung development, may create its own set of morbidities that counteract many of the benefits derived from ductus closure.
Platelets contribute to postnatal occlusion of the ductus arteriosus
TLDR
It is shown that platelets have an essential role in DA closure by promoting thrombotic sealing of the constricted DA and by supporting luminal remodeling.
Safety and efficacy of ibuprofen versus indomethacin in preterm infants treated for patent ductus arteriosus: a randomised controlled trial
TLDR
It is confirmed that, by comparison with indomethacin, ibuprofen has fewer effects on renal function in terms of urine output and fluid retention, with much the same efficacy and safety in closing patent ductus arteriosus in preterm infants with respiratory distress syndrome.
Effect of ampicillin on bleeding time in very low birth-weight neonates during the first week after birth
TLDR
Over the first week of life, a period when the bleeding time of VLBW neonates normally shortens, the opposite occurred (the bleeding time lengthened) if ⩾10 doses of ampicillin were administered.
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