Thrombocytopenia in septicemia: the role of disseminated intravascular coagulation.

  title={Thrombocytopenia in septicemia: the role of disseminated intravascular coagulation.},
  author={P B Neame and John G. Kelton and I Rev. Lucius Walker and Ian Stewart and Hymie L. Nossel and Jack Hirsh},
  volume={56 1},
The mechanism of isolated thrombocytopenia in septicemia is unknown, but compensated disseminated intravascular coagulation (DIC) has been suggested as a possible cause. To investigate this possibility, platelet counts and sensitive assays for in vivo thrombin and plasmin generation, including fibrinogen gel chromatography and fibrinopeptide A (FPA) assays, were obtained on 31 septicemic patients. Fifteen of 17 patients with gram-negative septicemia and 8 of 14 patients with gram-positive… CONTINUE READING
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