Thrombocytopenia in adults: A practical approach to evaluation and management.

  title={Thrombocytopenia in adults: A practical approach to evaluation and management.},
  author={Sudhir Singh Sekhon and Vivek Roy},
  journal={Southern medical journal},
  volume={99 5},
          491-8; quiz 499-500, 533
With the widespread use of automated cell counters, clinicians in any field of medicine may encounter thrombocytopenia. The symptomatology may vary greatly and the underlying cause may be either inconsequential (pseudothrombocytopenia) or life threatening. It is important to be aware of common conditions leading to thrombocytopenia and have a systematic approach to evaluation and management of these patients. In this review we highlight common etiologies seen in adult patients with… 

Evaluation of Thrombocytopenia in a Tertiary Care Centre

Thrombocytopenia has a wide spectrum of causes which can be diagnosed by detailed history and peripheral smear examination supported by bone marrow examination and other relevant investigations, and is found to be drugs, chronic liver disease, multiple myeloma and others.

Clinicopathological Study of Non – ImmuneThrombocytopenia

The Analysis of Adult Patients Confirmed With Thrombocytopenia Using Clinical and Relevant Laboratory parameters to Assure At A Possible Aetiopathogenesis is focused on.

Narrative Review on Different Clinical Aspects of Thrombocytopenia

The major causes of thrombocytopenia are summarized, the main general symptoms are characterized and the diagnosis and treatment methods are summarized.

Thrombocytopenia: an update

This review article aims to summarize and address appropriate work‐up of the major and/or life‐threatening causes of thrombocytopenia and some of the better‐characterized congenital thromBocy topenias.

[Acute profound thrombocytopenia associated with tirofiban: clinical approach to diagnosis and therapeutic management].

A case of a patient with acute coronary syndrome scheduled for urgent percutaneous coronary intervention who developed acute profound thrombocytopenia during treatment with intravenous tirofiban and was treated with steroids, immunoglobulin and platelet transfusion.

Clinicopathological Study of Non-Immune Thrombocytopenia in Adults

This prospective study focuses on the analysis of adult patients confirmed with thrombocytopenia using clinical and relevant laboratory parameters to arrive at a possible aetiopathogenesis.


Thrombocytopenia is a major cause of abnormal bleeding in many cases and it is important to diagnose it early as the treatment differs depending upon the etiology, hence clinic-pathological approach is important in these cases.

Thrombocytopenia in Adults: Review Article

Both hereditary and acquired reasons help thrombocytopenia have wide spreaded, but acquired causes are more common with increasing age, according to geographical distribution and application centers.

Idiopathic thrombocytopenic purpura: laboratory diagnosis and management

Management of ITP is based on platelet count and severity of bleeding, and treatment is aimed at interfering with antibodies that damage the platelets, by inhibiting the functions of macrophage Fca receptors and decreasing the production of antiplatelet antibodies.



Therapy for Adults with Refractory Chronic Immune Thrombocytopenic Purpura

Adult chronic immune thrombocytopenic purpura (ITP) is an autoimmune disorder caused by one or more antiplatelet autoantibodies usually directed to the platelet glycoprotein IIb/IIIa complex, GPIb/IX

Idiopathic thrombocytopenic purpura: a practice guideline developed by explicit methods for the American Society of Hematology.

This report begins with a brief summary of the panel’s recommendations, followed by a more detailed analysis of its methodology, the findings of the comprehensive literature review, and a full presentation of the recommendations.

How I treat patients with thrombotic thrombocytopenic purpura-hemolytic uremic syndrome.

Although the increased survival rate is dramatic and recent advances in understanding the pathogenesis of these syndromes are remarkable, clinical decisions remain empirical, and the management decisions for patients with suspected TTP-HUS rely on individual experience and opinion, resulting in many different practice patterns.

Incidence and Diagnosis of EDTA‐Dependent Pseudothrombocytopenia in a Consecutive Outpatient Population Referred for Isolated Thrombocytopenia

Cases of EDTA‐dependent pseudothrombocytopenia (EDTA‐PTCP) were identified and the diagnosis was confirmed by the following findings: normal platelet numbers immediately after blood withdrawal; progressive fall of platelet counts and evident platelet clumping over time, only in EDTA-anticoagulated blood.

Incidence of thrombocytopenia in an acute care hospital.

The high association between thrombocytopenia and infection justifies a search for an infective process when one encounters an unexpected or unexplained reduction in the platelet count.

The incidence of idiopathic thrombocytopenic purpura in adults increases with age.

The incidence rate of idiopathic thrombocytopenic purpura in Danish adults diagnosed from April 1, 1973 to December 31, 1995 increased in the study period, and involved asymptomatic patients and old males who were both symptomatic or not symptomatic.

Heparin-induced thrombocytopenia: recognition, treatment, and prevention: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy.

This chapter about the recognition, treatment, and prevention of heparin-induced thrombocytopenia (HIT) is part of the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy: Evidence

Incidence of thrombocytopenia in an acute care hospital.

  • C. TeoY. Kueh
  • Medicine
    Annals of the Academy of Medicine, Singapore
  • 1989
The high association between thrombocytopenia and infection justifies a search for an infective process when one encounters an unexpected or unexplained reduction in the platelet count.

Platelet transfusion for patients with cancer: clinical practice guidelines of the American Society of Clinical Oncology.

The possible consequences of different approaches to the use of platelet transfusion were considered in evaluating a preference for one or another technique producing similar outcomes and cost alone was not a determining factor.