Thrombocyte HLA molecules retain nonrenewable endogenous peptides of megakaryocyte lineage and do not stimulate direct allocytotoxicity in vitro.

@article{Gouttefangeas2000ThrombocyteHM,
  title={Thrombocyte HLA molecules retain nonrenewable endogenous peptides of megakaryocyte lineage and do not stimulate direct allocytotoxicity in vitro.},
  author={C{\'e}cile Gouttefangeas and Marianne Diehl and Wieland Keilholz and R. F. H{\"o}rnlein and Stefan Stevanovi{\'c} and Hans Georg Rammensee},
  journal={Blood},
  year={2000},
  volume={95 10},
  pages={3168-75}
}
The origin and the function of HLA class I molecules present on the surface of human platelets are still unclear. In particular, it is controversial which fraction of these class I molecules represents integral membrane components derived from the megakaryocyte-platelet lineage versus soluble plasma HLA molecules acquired by adsorption. Results of the present study show that HLA-A2 ligands isolated from platelets possess the same peptide motif as described for HLA-A2-associated peptides… CONTINUE READING

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