Thrombin stimulates RPE cell proliferation by promoting c-Fos-mediated cyclin D1 expression.

@article{Parrales2010ThrombinSR,
  title={Thrombin stimulates RPE cell proliferation by promoting c-Fos-mediated cyclin D1 expression.},
  author={Alejandro Parrales and Jos{\'e} Prisco Palma-Nicol{\'a}s and Edith T. Lopez and Ana Mar{\'i}a L{\'o}pez-Colom{\'e}},
  journal={Journal of cellular physiology},
  year={2010},
  volume={222 2},
  pages={302-12}
}
The retinal pigment epithelium (RPE) plays an essential role in the maintenance and normal functioning of the neural retina. Alterations in RPE function are involved in several ocular pathologies involving the breakdown of the blood-retina barrier (BRB), which exposes RPE to serum components, thrombin among them. Our previous work has shown that thrombin stimulates the proliferation of RPE cells. We here analyzed the molecular pathways leading to this outcome, in order to support thrombin… CONTINUE READING