Thrombin signalling and protease-activated receptors

@article{Coughlin2000ThrombinSA,
  title={Thrombin signalling and protease-activated receptors},
  author={S. Coughlin},
  journal={Nature},
  year={2000},
  volume={407},
  pages={258-264}
}
  • S. Coughlin
  • Published 2000
  • Medicine, Biology
  • Nature
  • How does the coagulation protease thrombin regulate cellular behaviour? The protease-activated receptors (PARs) provide one answer. In concert with the coagulation cascade, these receptors provide an elegant mechanism linking mechanical information in the form of tissue injury or vascular leakage to cellular responses. Roles for PARs are beginning to emerge in haemostasis and thrombosis, inflammation, and perhaps even blood vessel development. 
    2,175 Citations
    Orchestration of coagulation protease signaling by tissue factor.
    • 86
    Protease-activated receptors in vascular biology.
    • S. Coughlin
    • Medicine, Biology
    • Thrombosis and haemostasis
    • 2001
    • 229
    • PDF
    Science review: Role of coagulation protease cascades in sepsis
    • 106
    COAGULATION CASCADE | Thrombin
    • 1
    Tissue factor, protease activated receptors and pathologic heart remodelling.
    • 16
    • Highly Influenced
    • PDF
    Protease receptor antagonism to target blood platelet therapies
    • 8
    Protease-activated receptors: how proteases signal to cells.
    • 100

    References

    SHOWING 1-10 OF 65 REFERENCES
    Inflammation, sepsis, and coagulation.
    • 258
    • PDF
    How the protease thrombin talks to cells.
    • S. Coughlin
    • Medicine, Biology
    • Proceedings of the National Academy of Sciences of the United States of America
    • 1999
    • 528
    • PDF
    Platelet-activating factor (PAF): signalling and adhesion in cell-cell interactions.
    • 66
    PAR3 is a cofactor for PAR4 activation by thrombin
    • 506
    Kinetics of thrombin receptor cleavage on intact cells. Relation to signaling.
    • 197
    Cathepsin G Activates Protease-activated Receptor-4 in Human Platelets*
    • 290
    • PDF
    A dual thrombin receptor system for platelet activation
    • 926