Thrombin signalling and protease-activated receptors

@article{Coughlin2000ThrombinSA,
  title={Thrombin signalling and protease-activated receptors},
  author={S. Coughlin},
  journal={Nature},
  year={2000},
  volume={407},
  pages={258-264}
}
  • S. Coughlin
  • Published 2000
  • Medicine, Biology
  • Nature
  • How does the coagulation protease thrombin regulate cellular behaviour? The protease-activated receptors (PARs) provide one answer. In concert with the coagulation cascade, these receptors provide an elegant mechanism linking mechanical information in the form of tissue injury or vascular leakage to cellular responses. Roles for PARs are beginning to emerge in haemostasis and thrombosis, inflammation, and perhaps even blood vessel development. 
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    • 1,412
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    • 955
    • PDF
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    • 228
    • PDF
    Inflammation and coagulation
    • 569
    G-protein-coupled receptors and cancer
    • 1,054
    Proteinase-activated receptors.
    • 1,213
    • PDF
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    • 540
    • PDF

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 65 REFERENCES
    A dual thrombin receptor system for platelet activation
    • 915
    How the protease thrombin talks to cells.
    • 525
    • PDF
    PAR3 is a cofactor for PAR4 activation by thrombin
    • 503
    Blood-borne tissue factor: another view of thrombosis.
    • 966
    • PDF