Thrombin receptors activate G(o) proteins in endothelial cells to regulate intracellular calcium and cell shape changes.

@article{Vanhauwe2002ThrombinRA,
  title={Thrombin receptors activate G(o) proteins in endothelial cells to regulate intracellular calcium and cell shape changes.},
  author={Jurgen F.M. Vanhauwe and Tarita O. Thomas and Richard D Minshall and Chinnaswamy Tiruppath{\`i} and Anli Li and Annette Gilchrist and Eun-ja Yoon and Asrar B. Malik and Heidi E. Hamm},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 37},
  pages={34143-9}
}
Thrombin receptors couple to G(i/o), G(q), and G(12/13) proteins to regulate a variety of signal transduction pathways that underlie the physiological role of endothelial cells in wound healing or inflammation. Whereas the involvement of G(i), G(q), G(12), or G(13) proteins in thrombin signaling has been investigated extensively, the role of G(o) proteins has largely been ignored. To determine whether G(o) proteins could contribute to thrombin-mediated signaling in endothelial cells, we have… CONTINUE READING
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Atherosclerosis 147, (Suppl

  • W. R. Aengevaeren
  • 1999

Novel Pathways for Thrombin Receptor-activated Go Proteins 34149 by gest on D ecem er 28

  • J. L. Aschner, H. Lum, P. W. Fletcher, A. B. Malik
  • J. Cell. Physiol. 173,
  • 1997
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