Thrombin-receptor activation and thrombin-induced brain tolerance.

  title={Thrombin-receptor activation and thrombin-induced brain tolerance.},
  author={Yajun Jiang and Jimin Wu and Y -J. Hua and Richard F. Keep and Jianming Xiang and Julian T. Hoff and Guohua Xi},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  volume={22 4},
The authors previously found that pretreatment with a low dose of thrombin attenuates the brain edema induced by a large dose of thrombin or an intracerebral hemorrhage, and reduces infarct volume after focal cerebral ischemia (i.e., thrombin preconditioning). This study investigated whether thrombin preconditioning is caused by activation of the thrombin receptor, also called protease-activated receptor. In the in vivo studies, thrombin-induced brain tolerance was eliminated by RPPGF (Arg-Pro… CONTINUE READING
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