Thrombin receptor activating peptide (TRAP) stimulates mitogenesis, c-fos and PDGF-A gene expression in human vascular smooth muscle cells.

@article{Kanthou1995ThrombinRA,
  title={Thrombin receptor activating peptide (TRAP) stimulates mitogenesis, c-fos and PDGF-A gene expression in human vascular smooth muscle cells.},
  author={Chryso Kanthou and Omar Benzakour and Gautam Patel and John Deadman and Vijay Vir Kakkar and Florea Lupu},
  journal={Thrombosis and haemostasis},
  year={1995},
  volume={74 5},
  pages={1340-7}
}
The synthetic peptide SFLLRNPNDKYEPF, identical in sequence to the new amino-terminus of the thrombin receptor generated following cleavage of thrombin, acts a thrombin receptor agonist/activating peptide (TRAP). In this study, Northern blot analysis showed that cultured human vascular smooth muscle cells (HVSMC) express a thrombin receptor transcript. TRAP… CONTINUE READING