Thrombin receptor actions in neonatal rat ventricular myocytes.

  title={Thrombin receptor actions in neonatal rat ventricular myocytes.},
  author={T Jiang and Vladimir Kuznetsov and E. V. Pak and H. L. Zhang and Richard B. Robinson and Susan F. Steinberg},
  journal={Circulation research},
  volume={78 4},
Previous studies established that thrombin stimulates phosphoinositide hydrolysis and modulates contractile function in neonatal rat ventricular myocytes. The present study further defines the signaling pathways activated by the thrombin receptor and their role in thrombin's actions in cardiac myocytes. The thrombin receptor-derived agonist peptide (TRAP, a portion of the tethered ligand created by thrombin's proteolytic activity) stimulates the rapid and transient accumulation of inositol bis… CONTINUE READING


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