Thrombin is a pro-fibrotic factor for rat renal fibroblasts in vitro.

Abstract

BACKGROUND Generation of thrombin occurs in response to parenchymal injury. Thrombin not only converts plasma fibrinogen into an insoluble fibrin clot, but also potentially augments inflammation through receptor-mediated activity. This study examines whether thrombin may potentially exacerbate fibrosis by upregulating the function of interstitial… (More)

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