Thrombin inhibits myosin light chain dephosphorylation in endothelial cells.

@article{Shasby1997ThrombinIM,
  title={Thrombin inhibits myosin light chain dephosphorylation in endothelial cells.},
  author={D. Michael Shasby and Trevor Stevens and Douglas M. Ries and Alan B. Moy and Jyothi Kamath and Asha Kamath and Sandra S. Shasby},
  journal={The American journal of physiology},
  year={1997},
  volume={272 2 Pt 1},
  pages={
          L311-9
        }
}
Histamine and thrombin increase myosin light-chain kinase-mediated phosphorylation of myosin light chain (MLC) in human umbilical vein endothelial cells (HUVEC). The increase in MLC phosphorylation caused by thrombin persists longer (330 min) than the increase caused by histamine (<5 min), although both increase cell calcium similarly. We hypothesized that some of the longer duration of the increase in MLC phosphorylation caused by thrombin was because of inhibition of myosin dephosphorylation… CONTINUE READING
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