Thrombin inhibits intercellular calcium wave propagation in corneal endothelial cells by modulation of hemichannels and gap junctions.

@article{Dhondt2007ThrombinII,
  title={Thrombin inhibits intercellular calcium wave propagation in corneal endothelial cells by modulation of hemichannels and gap junctions.},
  author={Catheleyne D'hondt and Raf Ponsaerts and Sangly P Srinivas and Johan Vereecke and Bernard Himpens},
  journal={Investigative ophthalmology & visual science},
  year={2007},
  volume={48 1},
  pages={
          120-33
        }
}
PURPOSE Thrombin, a serine protease, breaks down the barrier integrity of corneal endothelial cells by phosphorylation of the regulatory light chain of myosin II (myosin light chain; MLC), which induces contractility of the actin cytoskeleton. This study was undertaken to investigate the effect of thrombin on gap junctional (GJIC) and paracrine (PIC) intercellular communication in cultured bovine corneal endothelial cells (BCECs). METHODS An intercellular Ca(2+) wave, a form of cell-cell… CONTINUE READING

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