Thrombin induces slug-mediated E-cadherin transcriptional repression and the parallel up-regulation of N-cadherin by a transcription-independent mechanism in RPE cells.

Abstract

The proliferation, directional migration to the vitreous and epithelial-mesenchymal transition (EMT) of quiescent, differentiated retinal pigment epithelium (RPE) cells is a major feature in the development of proliferative vitreoretinopathy (PVR) following exposure of the immuno-privileged eye niche to serum components, thrombin among them. We have… (More)
DOI: 10.1002/jcp.24165

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Cite this paper

@article{PalmaNicols2013ThrombinIS, title={Thrombin induces slug-mediated E-cadherin transcriptional repression and the parallel up-regulation of N-cadherin by a transcription-independent mechanism in RPE cells.}, author={Jos{\'e} Prisco Palma-Nicol{\'a}s and Ana Mar{\'i}a L{\'o}pez-Colom{\'e}}, journal={Journal of cellular physiology}, year={2013}, volume={228 3}, pages={581-9} }