Thrombin-induced phosphodiesteratic cleavage of phosphatidylinositol bisphosphate in human platelets.

@article{Agranoff1983ThrombininducedPC,
  title={Thrombin-induced phosphodiesteratic cleavage of phosphatidylinositol bisphosphate in human platelets.},
  author={Bernard W. Agranoff and Pushpalatha P. N. Murthy and Edward B. Seguin},
  journal={The Journal of biological chemistry},
  year={1983},
  volume={258 4},
  pages={
          2076-8
        }
}
The addition of thrombin to human platelets prelabeled with 32Pi led to significant loss of radioactivity in phosphatidylinositol 4,5-bisphosphate within 5 s, followed by recovery or even increase by 2 min. Loss of label from phosphatidylinositol phosphate was much less marked. Stimulated loss of label from phosphatidylinositol was not seen, while labeled phosphatidate increased severalfold. The principal labeled water-soluble phosphates observed, in addition to 32Pi and [32P] ATP, co-migrated… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 38 CITATIONS

Similar Papers

Loading similar papers…